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This is a very subjective question. The easy answer would be depends on the person and the "punch". A single blow to the kidney, spleen, liver, or trachea could easily kill due to internal bleeding or edema. Training will help a person be able to remain focused but the damage will still be done. We are both really resilient and fragile at the same time. When we excede speeds that our own bodies can generate the risk of serious injury goes up with the speed and we need more protection.
"The easy answer would be depends"
that is exactly the truth...it is that every tiny bit of a variable in a fight can change the outcome. Sure there are odds on strong possibilities but just like football "on any given Sunday..." So I have seen guys able to take a strong punch to the trachea without a flinch and have seen big strong dudes flop from a quickly delivered temple shot... as you said, it depends.
Training and awareness (and luck) seem to play the major rolls in successful fighting.
That's what science is about: learning the average response and taking note of the extremes. Martial arts are generally based on what works on the average man the system has encountered. Though, chuckle, a lot of martial arts have lost their way.
Mythbusters!
stupid! the only answer is "as many as "he" takes until he dies (or is brain-damaged enough to not be able to keep fighting). won't be any research going that far (except in real life)
Hopefully the researchers will look at the gloves that fighters are using. The light-weight (6-8 oz) gloves we see now allow for full force punches without hurt or injury to the hand. Consequently, the head takes a harder punch (and more injury). Two factors are at play: 1. The mass of the glove adds to the impact, and 2. The swing has greater force.
Boxers suffer a higher rate of head injury (or so I understand) because the big gloves they use soften the blow to the hand but not the head. Could it be that bare fisted fighting is safer than the light weight gloves used now? Researchers should investigate and the fighters, promoters, and regulators should heed the results of such research.
Judging by how many Obama takes on a daily basis, (mostly due to his own ignorance), I'd say a lot.