Panelists highlighted side effects including suicidal thoughts, memory lapses and birth defects
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from:msnbc.comFDA rejects second weight-loss drug in a week
Seeded on Fri Oct 29, 2010 5:29 AM EDT (msnbc.com)
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Exercise!
Exercise?!?!?! roflmao! If you eat 8000 calories in a day, which is easy for some fata$$e$, and your basal metabolic rate is 2200 calories burned in a day, burning 500 calories on a treadmill is going to be a joke! You have still overeaten 5300 calories! You would have to run 2 marathons to burn off that one day of eating! The answer is to EAT LESS!
Eat less AND exercise.
Actually the answer is not only to eat less and exercise more but it is to scrap the USDA recommended daily allowances for calorie, carbohydrate, etc. intake. Man was evolved on a diet that did not include 220g of carbohydrates per day. The human body needs something akin to about 70 g of carbohydrates which are turned into glucose to feed our brains. Anything above that goes to fat storage. There is a direct corelation with the growth of Americans (obesity) and the introduction of the food pyramid.
The US Department of Agriculture (read the last word) owns the food pyramid and they represent who? So naturally the guidelines were setup to protect their interests (the interests of farmers).
If you would like to lose weight multiply your weight in pounds by 11 and eat only that amount of balanced calories. Example: If you weight 200 pounds and want to lose weight, consume only 2200 calories and you will lose weight. It is thermodynamics folks, how much energy (calories) does it take to heat 200 pounds of water (human body) to a temperature of 98.6 for 24 hours against an ambient temperature of 70. As you lose weight you continue to change your calorie intake. It is that simple. If you weigh 500 lbs, you will lose weight if you eat 5500 calories daily with only light exercise. Fact.
@rational-that's interesting-what's your source? I'd like to think that this would work-in fact I think I will try instead of this 1500 calorie thing where the brain thinks of nothing BUT food! Perhaps this is rational!
I always wondered why people can't lose weight on 1500 calories or 1800 calories-might it be because the body goes into starvation mode and starts storing fat in case it needs it, hence no weight lose?
look at the book, The Paleo Solution by Robb Wolf. He explains all of that very well.
Actually, any doctor or biologist would tell you that exercise might help, but it's hardly the cause or solution to the problem.
sophie -
My wife is a dietician - she showed me all kinds of stuff over the years. Once she showed me a formula she used to determine the proper calorie intake for an individual. I realized it was a heat transfer /thermodynamics calculation (I am a Mechanical engineer). The formula is for how much energy does it take to heat a mass of water. The body is 90+% water so it is assumed to be pure for the purpose of the calculation. So it can be reduced down to a simple statement of how much heat energy is required to hold a spherical mass of water to a temperature for a time period.
All humans have a +30 degree temperature that must be maintained because we are warm blooded.
Any energy we exert beyond that results in weight loss.
My wife counsels obese people one on one. This is the formula she uses with great success. One person she has worked with for 15 months has lost 187 lbs using this formula and light to moderate exercise. Slow and steady has cut this woman in half and she continues to be successful in her persuit of her goal (another 40 lbs).
A great book to read is a diet book called "The Zone" by Dr. B. Sears if you would like to understand the way the body works with carbohydrates, how the liver functions, what are its limitations, what happens to glucose, and so on.
Best of luck in your quest for health.
BTW - I use the formula to maintain my weight to. I am a 44 year old, 6 foot male and weigh 178 lbs and do moderate exercise. I maintain my weight by multiplying my weight by 14 to know how much my daily calorie content should be. For me that is 2500 calories a day. And I have maintained that weight for 9 years now.
You will never solve a problem at the level of the effect. Obesity is an effect, result, symptom. Taking a pill to cure obesity? Are you serious?
STOP FREAKING OVEREATING!!!!!! That'll fix you fata$$e$. I am amazed at the stupidity when it comes to being fat. I don't care WHAT diseases you have to blame on being fat. Eat less calories than you burn in a day and you WILL LOSE WEIGHT!
Wow, all that brain power, education, and reason in one package, topped of with such amazing language! What a winner!
The cure is called EXERCISE!!!
Nonsense.
I actually bought put options on VVUS a few months ago, ahead of their preliminary ruling. There was no way this drug would ever be approved. Here's my take on what we need to do for healthcare in the US:
http://www.halfbakedlunatic.com/post/2010/10/25/Tackling-the-Healthcare-Issue.aspx
Excellent article! Bravo! I wish more people were aware of how out-of-hand our whole medical system has gotten...
The drug companies make too much money treating diabetes , finding a drug to help people loss weight doesn't benefit them.
The FDA should be going after the food companies for putting so much CRAP in the food supply! Not to mention, the meat and dairy industry has spent decades convincing us that we should have several servings of these fattening selections a day. Our lifestyles are busy. Even things like Lean Cuisine and Healthy Choice dinners are 80% chemicals! The American body has adapted to these nasty artificial ingredients. Europeans and Asians eat more fresh foods and things like fruit for dessert instead of sugary sweets. Exercise, FRESH food, and eating in moderation is key!!
I forgot to mention the FDA WON'T go after the food industry because it makes too much money. It's all about the money, folks, NOT your health! Now they want to ban natural supplements and vitamins!! All because they can't patent them and make billions. They want to take control of your own health OUT of your hands so you will eventually be forced to buy their drugs. Don't even get me started on genetically modified food!
The only drug that might work is one that inhibits the ability to store energy OR destroy brown fat cells. Anything else is just a pep pill.
It is called self control...No ones fault except tthe one eating...Exercise more and eat less. It is not the FDA's fault or the food industry. If you choose to eat several portions of any food and not exercise you get fat.
It's about one #@)$* of a lot more than self-control, particularly if you any health problems that are not related to being overweight.
Perhaps you'd like to try standing and cooking from scratch (which does help) when your feet are extremely pain from from an inflammatory problem. Perhaps you'd like to try standing and cooking from scratch when that same inflammatory problems also affects your wrists, hands and fingers. Or perhaps you'd like to try it with any number of different spinal problems.
None of these are problems that aer weight-related, and yet every one of them, and many, many others affect your ability to cook for yourself, to exercise, to do much of anything that will help you to lose any extra weight.
Welcome to MY world, one from which you'd be screaming to get out after 10 minutes in my shoes.
I'll accept your apology at any time.
Don't hold your breath...I have had arthiritis for years in both my hands and knees and I still find time to teach full-time and make dinner everynight. You can prepare a healthy meal from scratch in less than 30 minutes. AND if you have the health problems you claim to your DR. has been on your case already.
Actually, any physician or doctor will tell you that's nonsense in a vast majority of cases.
For many people, the problems comes down to a lack of education. Many people, including some of those at a normal weight, simply don't understand the fundamentals of nutrition. Learning how to manage your body needs to be made a priority in schools and community outreach projects. Even beyond fat loss, it's imperative for people to learn how to feed themselves in such a way that they can understand the likely effects of their actions and predict the outcome. Without basic knowledge of nutrition and human metabolism, eating can be a confusing and frustrating exercise that has to be done every day whether they want to or not. Educate yourself and others about nutrition. Knowledge is the predecessor to progress and we need action now more than ever. We have to stop the cycle of bad habits and irresponsible nutrition now with education through schools and the community. Make a difference in your life and in the lives of those in need. Rational, effective nutrition for fat loss and long-term health: http://www.NutritionPerfected.com
And when they don't apply because of other legitimate health challenges? Such problems do exist. What's the advice you would give to those of us with such other problems?
And there is a whole host of other issues going on as well. Sorry, much of the time, nutrition is not an issue.
Guess what,kids? There's no majic pill ( at least a safe one ).available today.Lose weight,and keep it off,the old fashioned way.Watch what you eat and the amount you eat.I dropped thirty pounds this way and have kept it off for four years.
Not always applicable!!!!!!!!!
There is no need for prescription diet aids as there are a number of natural safe effective non-prescription products available some of which even have real money back guarantees. Life Extension's Irvingia Optimized has positively been reviewed on Dr Oz and the show "The Doctors" and has clinical double blind trials published in several leading medical journals. It shows not only significant weight loss without caffeine or ephedra but also reduced LDL cholesterol, CRP, fasting glucose and targets primarilary abdominal fat. Slimor and Slimax are both made in USA and all natural burn fat lead to rapid weight loss without significant side effects other than increased energy and thirst. These are available on Ebay and Amazon as well as better supplement stores.
Yes, random combinations of garbage with absolutely no safety or efficacy testing should be taken by *everyone*! NOT. These products are invariably shown to be a scam. Invariably. if they worked, pharma would have them out in an FDA approved drug.
Missin g the big picture folks. The FDA and CMS are taking queues from BHO and friends to squash approvals unless they have no choice but to accept the data and the safety data is pristine. They are also looking into the cost. All part of controlling health care spending to pay for single payer.
I just finished reading all of the comments prior to mine and they are very critical of those with weight problems. Yes may eat too much and the wrong things but there are also a large number that have insulin or Leptin resistance that is usually genetically linked. Fortunately several natural herbs help overcome these. The Mediterranean diet with more seafood and spices and some red wine with lots of greens is very healthy but too expensive for many particularly in this current US economy. There are healthy inexpensive alternatives to fast food that work for these people but they have to be guided and be willing to modify behaviors along with taking some inexpensive supplements to help them overcome posible genetic burdens.
That's a much better and more appropriate post than most have left here on this topic. At least you're offering reasonable alternatives, and recognizing that there is a fiscal component to this, for just about everyone. That also includes those "inexpensive" supplements. If you constantly have to chose between, say, paying the rent and putting food on the table, then those supplements may as well cost billions of dollars/dose.
However, even for those who can afford to eat properly, there are still health challenges other than those that you mentioned early in your post, that can still leave people unable to keep their weight down to, or up to, a healthy level. Being seriously underweight is a dangerous as is being obese.
It's been shown repeatedly that naturally thin people (with high metabolisms, absorption issues, etc.) have no real idea that there are people out there twice their size that eat less, exercise far (far) more, and eat better foods and are still too heavy. The level is ignorance is pretty extreme. Personally, I find it rather obnoxious that these same people seem to love to flout their lack of knowledge in the most nasty, mean-spirtited ways.
WTF with all of the quick fixes? Why is it so hard for people to educate themselves on proper nutritional choices and getting a little exercise.
Let me turn that question around. Why is it so hard for people to educate themselves on the fact that it's not just about nutrition and exercise?
And why is it so hard for people like you to grasp that many of those people you seem to dislike so intensely make better choices, eat less, exercise more, and are still heavy? Or have to make multiple times the effort that you make due to medical causes, genetics, differing microflora, prescritption drugs, or any number of other reasons.
There is no market for a diet pill. Look around you, nobody wants to loose weight. We are a country of fat happy people.
Here's a safe way to shed pounds. Eat right and exercise
Instead of eat less,eat better,try Low Carb diet,in any modality,you will feel satiated,energized,and weight loss and overall health is a consequence.lmb
Turn your brain on, read the food's you eat ingredient list and avoid foods with unhealthy ingredients (after researching what is unhealthy), AND MOST IMPORTANTLY - as mentioned by everyone else - exercise. Excercise does not cause birth defects, and if you pace your self, shouldnt kill you.
Surprised the Chamber of Commerce isn't screaming about the results. Why should government interfere with business is all they care about.
eat less, exercise more...it sucks but it's the only way.
http://www.naturalnews.com/030209_placebo_medical_fraud.html
This is more about clinical trials.
Whoo! *Naturalnews*! Is the janitor from my building the senior editor? I'll rush right over to the fiction section for my latest copy!
I take Topamax daily. It took 3 tries before I could handle it on a daily basis. I take it to prevent migraines. I had daily cluster migraines that no meds would help. So It works great and keeps almost all migraines away. But the side effects are HORRIBLE. Will you lose weight??? YES...At first You'll lose up to 10-12 pounds. It doesn't matter what you eat it just falls off, plus there's a huge loss of appetite. But then that's it. It Stops. No further loss. If you go off the drug you'll start to gain it back, And if you go off and then get back on after awhile. You never again get that weight loss effect like you did at first. But with it comes. Huge vision loss went from -5.75 to to a -7.00, Vision blurriness, Electric shock pains in your feet, All carbonated drinks taste horrible (gets better with time) But the worst thing is it makes you Retarded!!! Lots of brain fogginess and short term memory loss. Sometimes when you fill out paperwork you cant remember your address, or phone number, or age. Your always at a loss for words. Its like your life is the game password. I'll say to my husband. Can you get me a uhh you know. the thing you eat with....." I know what I want, I see a pic of it in my head, So I just describe it and he'll say "fork?" and I'll say yes thats it. That happens all the times. Sometimes your just blank and stare at the wall for awhile and don't realize it. What a scary drug for the masses to take who want a miracle cure to lose weight. 1/3 we eat too much with no exercise, 1/3 there's all this crap and chemicals in the food that make us fat, 1/3 metabolism/genetics You got a good one or you don't. My husband couldn't gain weight if he tried. Some people look at a cheesecake at get fat. But Watch the tv show biggest loser, anyone can lose weight with just diet and exercise. It just sucks and it's hard......It would be nice to have a pill that could help. But this combo would not be good. Topomax is hard enough for before who medically need it. Add a meth-speed like substance to it.....It would be a disaster.
I too was prescribed Topamax as a prophylactic for my migraines. I wasn't even aware that it caused weight loss, as I stopped taking it quickly after I realized the brain fogginess and speech impairment. As an attorney, I had to will myself to maintain focus and control my speech in court.
I take Topamax daily. It took 3 tries before I could handle it on a daily basis. I take it to prevent migraines. I had daily cluster migraines that no meds would help. So It works great and keeps almost all migraines away. But the side effects are HORRIBLE. Will you lose weight??? YES...At first You'll lose up to 10-12 pounds. It doesn't matter what you eat it just falls off, plus there's a huge loss of appetite. But then that's it. It Stops. No further loss. If you go off the drug you'll start to gain it back, And if you go off and then get back on after awhile. You never again get that weight loss effect like you did at first. But with it comes. Huge vision loss went from -5.75 to to a -7.00, Vision blurriness, Electric shock pains in your feet, All carbonated drinks taste horrible (gets better with time) But the worst thing is it makes you Retarded!!! Lots of brain fogginess and short term memory loss. Sometimes when you fill out paperwork you cant remember your address, or phone number, or age. Your always at a loss for words. Its like your life is the game password. I'll say to my husband. Can you get me a uhh you know. the thing you eat with....." I know what I want, I see a pic of it in my head, So I just describe it and he'll say "fork?" and I'll say yes thats it. That happens all the times. Sometimes your just blank and stare at the wall for awhile and don't realize it. What a scary drug for the masses to take who want a miracle cure to lose weight. 1/3 we eat too much with no exercise, 1/3 there's all this crap and chemicals in the food that make us fat, 1/3 metabolism/genetics You got a good one or you don't. My husband couldn't gain weight if he tried. Some people look at a cheesecake at get fat. But Watch the tv show biggest loser, anyone can lose weight with just diet and exercise. It just sucks and it's hard......It would be nice to have a pill that could help. But this combo would not be good. Topomax is hard enough for before who medically need it. Add a meth-speed like substance to it.....It would be a disaster.
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